April 19th, 2020

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О сколько нам открытий чудных
Готовит просвещенья дух
И опыт, сын ошибок трудных,
И гений, парадоксов друг,
И случай, бог изобретатель...



"... we demonstrate the de novo biosynthetic production of psilocybin and related tryptamine derivatives in Saccharomyces cerevisiae by expression of a heterologous biosynthesis pathway sourced from Psilocybe cubensis. Additionally, we achieve improved product titers by supplementing the pathway with a novel cytochrome P450 reductase from P. cubensis. Further rational engineering resulted in a final production strain producing 627 ± 140 mg/L of psilocybin and 580 ± 276 mg/L of the dephosphorylated degradation product psilocin in triplicate controlled fed-batch fermentations in minimal synthetic media."



вот здесь подробности для любознательных и пытливых умом, да
promo kurgypster september 21, 2012 03:18 164
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